Identification of Two Novel Carbapenemase-Encoding Hybrid Plasmids Harboring bla_NDM-5 and bla_KPC-2 in a Clinical ST11-KL47 Klebsiella pneumoniae.

ABSTRACT:

Background

Emergence of bla_KPC and bla_NDM co-harboring Klebsiella pneumoniae has escalated the threat of Carbapenem-resistant Klebsiella pneumoniae (CRKP) to healthcare. It remains unknown the prevalence and molecular characteristics of CRKP co-producing KPC and NDMs carbapenemases in Henan.

Methods and results

Twenty-seven CRKP strains isolated from different times were selected randomly in affiliated cancer hospital of Zhengzhou University from January 2019 to January 2021, among which one KPC-2 and NDM-5 positive CRKP named K9 was isolated from an abdominal pus sample of a 63-year-old male patient with leukemia. Sequencing of K9 determined that K9 belonged to ST11-KL47, which is resistant to antibiotics such as meropenem,

SUBMITTER: Xiao W 

PROVIDER: S-EPMC10305773 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature