Sequence-assignment validation in protein crystal structure models with checkMySequence.
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ABSTRACT:
SUBMITTER: Chojnowski G
PROVIDER: S-EPMC10306063 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Publications
Sequence-assignment validation in protein crystal structure models with checkMySequence.
Acta crystallographica. Section D, Structural biology 20230614 Pt 7
Sequence-register shifts remain one of the most elusive errors in experimental macromolecular models. They may affect model interpretation and propagate to newly built models from older structures. In a recent publication, it was shown that register shifts in cryo-EM models of proteins can be detected using a systematic reassignment of short model fragments to the target sequence. Here, it is shown that the same approach can be used to detect register shifts in crystal structure models using sta ...[more]
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