In situ oxidative polymerization of platinum(iv) prodrugs in pore-confined spaces of CaCO₃ nanoparticles for cancer chemoimmunotherapy.

ABSTRACT: Drug resistance and metastases are the leading causes of death in clinics. To overcome this limitation, there is an urgent need for new therapeutic agents and drug formulations that are able to therapeutically intervene by non-traditional mechanisms. Herein, the physical adsorption and oxidative polymerization of Pt(iv) prodrugs in pore-confined spaces of CaCO₃ nanoparticles is presented, and the nanomaterial surface was coated with DSPE-PEG₂₀₀₀-Biotin to improve aqueous solubility and tumor targeting. While the nanoparticle scaffold remained stable in an aqueous solution, it quickly degraded into Ca²⁺ in the presence of acid and into cisplatin in the presence of GSH. The nanoparticles were found to interact in cisplatin-resistant non-small lung cancer cell

SUBMITTER: Wei F 

PROVIDER: S-EPMC10306087 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature