Design and test of a rigid endomicroscopic system for multimodal imaging and femtosecond laser ablation.

ABSTRACT:

Significance

Conventional diagnosis of laryngeal cancer is normally made by a combination of endoscopic examination, a subsequent biopsy, and histopathology, but this requires several days and unnecessary biopsies can increase pathologist workload. Nonlinear imaging implemented through endoscopy can shorten this diagnosis time, and localize the margin of the cancerous area with high resolution.

Aim

Develop a rigid endomicroscope for the head and neck region, aiming for in-vivo multimodal imaging with a large field of view (FOV) and tissue ablation.

Approach

Three nonlinear imaging modalities, which are coherent anti-Stokes Raman scattering, two-photon excitation fluorescence, and second harmonic generation, as well as the single photon fluorescence of indocyani

SUBMITTER: Lai C 

PROVIDER: S-EPMC10306116 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature