Opponent learning with different representations in the cortico-basal ganglia pathways can develop obsession-compulsion cycle.

ABSTRACT: Obsessive-compulsive disorder (OCD) has been suggested to be associated with impairment of model-based behavioral control. Meanwhile, recent work suggested shorter memory trace for negative than positive prediction errors (PEs) in OCD. We explored relations between these two suggestions through computational modeling. Based on the properties of cortico-basal ganglia pathways, we modeled human as an agent having a combination of successor representation (SR)-based system that enables model-based-like control and individual representation (IR)-based system that only hosts model-free control, with the two systems potentially learning from positive and negative PEs in different rates. We simulated the agent's behavior in the environmental model used in the recent work that describes potential

SUBMITTER: Sato R 

PROVIDER: S-EPMC10306209 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature