Timing of invasive mechanical ventilation and death in critically ill adults with COVID-19: A multicenter cohort study.

ABSTRACT:

Purpose

To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality.

Materials and methods

The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model.

Results

Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV ear

SUBMITTER: Green A 

PROVIDER: S-EPMC10306211 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature