Evolution of MHC IIB Diversity Across Cichlid Fish Radiations.

ABSTRACT: The genes of the major histocompatibility complex (MHC) are among the most polymorphic genes in vertebrates and crucial for their adaptive immune response. These genes frequently show inconsistencies between allelic genealogies and species phylogenies. This phenomenon is thought to be the result of parasite-mediated balancing selection maintaining ancient alleles through speciation events (trans-species polymorphism [TSP]). However, allele similarities may also arise from postspeciation mechanisms, such as convergence or introgression. Here, we investigated the evolution of MHC class IIB diversity in the cichlid fish radiations across Africa and the Neotropics by a comprehensive review of available MHC IIB DNA sequence information. We explored what mechanism explains the MHC allele similar

SUBMITTER: Lozano-Martin C 

PROVIDER: S-EPMC10306275 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature