Multiple sclerosis: Exploring the limits and implications of genetic and environmental susceptibility.

ABSTRACT:

Objective

To explore and describe the basis and implications of genetic and environmental susceptibility to multiple sclerosis (MS) using the Canadian population-based data.

Background

Certain parameters of MS-epidemiology are directly observable (e.g., the recurrence-risk of MS in siblings and twins, the proportion of women among MS patients, the population-prevalence of MS, and the time-dependent changes in the sex-ratio). By contrast, other parameters can only be inferred from the observed parameters (e.g., the proportion of the population that is "genetically susceptible", the proportion of women among susceptible individuals, the probability that a susceptible individual will experience an environment "sufficient" to cause MS, and if they do, the probability that they w

SUBMITTER: Goodin DS 

PROVIDER: S-EPMC10306391 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature