ERα-associated translocations underlie oncogene amplifications in breast cancer.

ABSTRACT: Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure^1-3 and the evolutionary trajectories⁴ of oncogene amplicons, their origin remains poorly understood. Here we show that focal amplifications in breast cancer frequently derive from a mechanism-which we term translocation-bridge amplification-involving inter-chromosomal translocations that lead to dicentric chromosome bridge formation and breakage. In 780 breast cancer genomes, we observe that focal amplifications are frequently connected to each other by inter-chromosomal translocations at their boundaries. Subsequent analysis indicates the following model: the oncogene neighbourhood is translocated in G1 creating a dicentric chromosome, the dicentric chro

SUBMITTER: Lee JJ 

PROVIDER: S-EPMC10307628 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature