PI16⁺ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.

ABSTRACT: Fibroblastic reticular cells (FRCs) direct the interaction and activation of immune cells in discrete microenvironments of lymphoid organs. Despite their important role in steering innate and adaptive immunity, the age- and inflammation-associated changes in the molecular identity and functional properties of human FRCs have remained largely unknown. Here, we show that human tonsillar FRCs undergo dynamic reprogramming during life and respond vigorously to inflammatory perturbation in comparison to other stromal cell types. The peptidase inhibitor 16 (PI16)-expressing reticular cell (PI16⁺ RC) subset of adult tonsils exhibited the strongest inflammation-associated structural remodeling. Interactome analysis combined with ex vivo and in vitro validation revealed that T cell activ

SUBMITTER: De Martin A 

PROVIDER: S-EPMC10307632 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature