The clonal heterogeneity of colon cancer with liver metastases.

ABSTRACT:

Background

Colon cancer with liver metastases (CCLM) characterized by genetic heterogeneity is an evolutionary process leading to variations in response to selective pressure, but the underlying evolutionary models still remains unclear.

Methods

Total of 30 samples, including primary tumor and two to four matched liver metastases from 8 treatment-naïve patients with CCLM were collected, and subjected to whole-exome DNA sequencing. PyClone was used to calculate intra and inter-tumor heterogeneity, LICHeE was used to reconstruct the cancer phylogeny trees and investigate the subclonal composition.

Results

The genetic differences were observed between primary and metastatic lesions, as well as among multiple metastases in all patients. The natural history models of color

SUBMITTER: Chen G 

PROVIDER: S-EPMC10307713 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature