Evaluating treatment options for cardiovascular autonomic neuropathy in patients with diabetes mellitus: a systematic review.

ABSTRACT:

Background

Cardiovascular autonomic neuropathy (CAN) is a debilitating complication of diabetes mellitus. To date, there is no systematic review on all the available drug treatments for CAN in diabetic patients, except for one review focusing on aldose reductase inhibitors.

Objective

To evaluate available drug treatment options for CAN in diabetic patients.

Methods

A systematic review was conducted with a search of CENTRAL, Embase, PubMed and Scopus from database inception till 14th May 2022. Randomised controlled trials (RCTs) of diabetic patients with CAN that investigated the effect of treatment on blood pressure, heart rate variability, heart rate or QT interval were included.

Results

Thirteen RCTs with a total of 724 diabetic patients with CAN were selecte

SUBMITTER: Goh JK 

PROVIDER: S-EPMC10307756 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature