Elevated third trimester corticosteroid levels are associated with fewer offspring infections.

ABSTRACT: Respiratory infections are a leading cause of morbidity and mortality in early life, and recurrent infections increase the risk of developing chronic diseases. The maternal environment during pregnancy can impact offspring health, but the factors leading to increased infection proneness have not been well characterized during this period. Steroids have been implicated in respiratory health outcomes and may similarly influence infection susceptibility. Our objective was to describe relationships between maternal steroid levels and offspring infection proneness. Using adjusted Poisson regression models, we evaluated associations between sixteen androgenic and corticosteroid metabolites during pregnancy and offspring respiratory infection incidence across two pre-birth cohorts (N = 774 in VDA

SUBMITTER: Prince N 

PROVIDER: S-EPMC10307773 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature