Modelled mortality benefits of multi-cancer early detection screening in England.

ABSTRACT:

Background

Screening programmes utilising blood-based multi-cancer early detection (MCED) tests, which can detect a shared cancer signal from any site in the body with a single, low false-positive rate, could reduce cancer burden through early diagnosis.

Methods

A natural history ('interception') model of cancer was previously used to characterise potential benefits of MCED screening (based on published performance of an MCED test). We built upon this using a two-population survival model to account for an increased risk of death from cfDNA-detectable cancers relative to cfDNA-non-detectable cancers. We developed another model allowing some cancers to metastasise directly from stage I, bypassing intermediate tumour stages. We used incidence and survival-by-stage data from th

SUBMITTER: Sasieni P 

PROVIDER: S-EPMC10307803 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature