The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma.

ABSTRACT: The ubiquitin-proteasome system governs a wide spectrum of cellular events and offers therapeutic opportunities for pharmacological intervention in cancer treatment. Renal clear cell carcinoma represents the predominant histological subtype and accounts for the majority of cancer death related to kidney malignancies. Through a systematic survey in the association of human ubiquitin-specific proteases with patient prognosis of renal clear cell carcinoma and subsequent phenotypic validation, we uncovered the tumor-promoting role of USP35. Biochemical characterizations confirmed the stabilizing effects of USP35 towards multiple members of the IAP family in an enzymatic activity-dependent manner. USP35 silencing led to reduced expression levels of IAP proteins, which were accompanied with incr

SUBMITTER: Wang S 

PROVIDER: S-EPMC10307860 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature