Qishen granules regulate intestinal microecology to improve cardiac function in rats with heart failure.

ABSTRACT:

Introduction

Qishen Granule (QSG), a clinically approved traditional Chinese medicine, has been researched for treating heart failure (HF) for many years. However, the effect of QSG on intestinal microecology remains unconfirmed. Therefore, this study aimed to elucidate the possible mechanism of QSG regulating HF in rats based on intestinal microecological changes.

Methods

A rat model with HF induced by myocardial infarction was prepared by left coronary artery ligation. Cardiac functions were assessed by echocardiography, pathological changes in the heart and ileum by hematoxylin-eosin (HE) and Masson staining, mitochondrial ultrastructure by transmission electron microscope, and gut microbiota by 16S rRNA sequencing.

Results

QSG administration improved cardiac funct

SUBMITTER: Gao K 

PROVIDER: S-EPMC10307979 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature