Gene expression of S100a8/a9 predicts Staphylococcus aureus-induced septic arthritis in mice.

ABSTRACT: Septic arthritis is the most aggressive joint disease associated with high morbidity and mortality. The interplay of the host immune system with the invading pathogens impacts the pathophysiology of septic arthritis. Early antibiotic treatment is crucial for a better prognosis to save the patients from severe bone damage and later joint dysfunction. To date, there are no specific predictive biomarkers for septic arthritis. Transcriptome sequencing analysis identified S100a8/a9 genes to be highly expressed in septic arthritis compared to non-septic arthritis at the early course of infection in an Staphylococcus aureus septic arthritis mouse model. Importantly, downregulation of S100a8/a9 mRNA expression at the early course of infection was noticed in mice infected with

SUBMITTER: Deshmukh M 

PROVIDER: S-EPMC10307981 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature