Leaderless secretory proteins of the neurodegenerative diseases via TNTs: a structure-function perspective.

ABSTRACT: Neurodegenerative disease-causing proteins such as alpha-synuclein, tau, and huntingtin are known to traverse across cells via exosomes, extracellular vesicles and tunneling nanotubes (TNTs). There seems to be good synergy between exosomes and TNTs in intercellular communication. Interestingly, many of the known major neurodegenerative proteins/proteolytic products are leaderless and are also reported to be secreted out of the cell via unconventional protein secretion. Such classes contain intrinsically disordered proteins and regions (IDRs) within them. The dynamic behavior of these proteins is due to their heterogenic conformations that is exhibited owing to various factors that occur inside the cells. The amino acid sequence along with the chemical modifications has implications on the

SUBMITTER: Padmanabhan S 

PROVIDER: S-EPMC10308029 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature