D-type K+ current rules the function of electrically coupled neurons in a species-specific fashion.

ABSTRACT: Electrical synapses supported by gap junctions are known to form networks of electrically coupled neurons in many regions of the mammalian brain, where they play relevant functional roles. Yet, how electrical coupling supports sophisticated network operations and the contribution of the intrinsic electrophysiological properties of neurons to these operations remain incompletely understood. Here, a comparative analysis of electrically coupled mesencephalic trigeminal (MesV) neurons uncovered remarkable difference in the operation of these networks in highly related species. While spiking of MesV neurons might support the recruitment of coupled cells in rats, this rarely occurs in mice. Using whole-cell recordings, we determined that the higher efficacy in postsynaptic recruitment in rat's M

SUBMITTER: Dapino A 

PROVIDER: S-EPMC10308032 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature