Anthracyclines and Biomarkers of Myocardial Injury: The Effect of Remote Ischemic Conditioning.

ABSTRACT:

Background

Remote ischemic conditioning (RIC) has been beneficial in laboratory studies of anthracycline cardiotoxicity, but its effects in patients is not established.

Objectives

The authors studied the effect of RIC on cardiac biomarkers and function during and after anthracycline chemotherapy.

Methods

The ERIC-Onc study (Effect of Remote Ischaemic Conditioning in Oncology Patients; NCT02471885) was a randomized, single-blind, sham-controlled study of RIC at each chemotherapy cycle. The primary endpoint was troponin T (TnT) during chemotherapy and up to 1 year. Secondary outcomes included cardiac function, major adverse cardiovascular events (MACE), and MACE or cancer death. Cardiac myosin-binding-protein C (cMyC) was investigated in parallel with TnT.

Results

SUBMITTER: Mallouppas M 

PROVIDER: S-EPMC10308041 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature