The genetic variability and evolution of red-spotted grouper nervous necrosis virus quasispecies can be associated with its virulence.

ABSTRACT: Nervous necrosis virus, NNV, is a neurotropic virus that causes viral nervous necrosis disease in a wide range of fish species, including European sea bass (Dicentrarchus labrax). NNV has a bisegmented (+) ssRNA genome consisting of RNA1, which encodes the RNA polymerase, and RNA2, encoding the capsid protein. The most prevalent NNV species in sea bass is red-spotted grouper nervous necrosis virus (RGNNV), causing high mortality in larvae and juveniles. Reverse genetics studies have associated amino acid 270 of the RGNNV capsid protein with RGNNV virulence in sea bass. NNV infection generates quasispecies and reassortants able to adapt to various selective pressures, such as host immune response or switching between host species. To better understand the variability of RGNNV populat

SUBMITTER: Ortega-Del Campo S 

PROVIDER: S-EPMC10308047 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature