Experimental infections in red-legged partridges reveal differences in host competence between West Nile and Usutu virus strains from Southern Spain.

ABSTRACT:

Introduction

West Nile virus (WNV) and Usutu virus (USUV) are emerging zoonotic arboviruses sharing the same life cycle with mosquitoes as vectors and wild birds as reservoir hosts. The main objective of this study was to characterize the pathogenicity and course of infection of two viral strains (WNV/08 and USUV/09) co-circulating in Southern Spain in a natural host, the red-legged partridge (Alectoris rufa), and to compare the results with those obtained with the reference strain WNV/NY99.

Methods

WNV inoculated birds were monitored for clinical and analytical parameters (viral load, viremia, and antibodies) for 15 days post-inoculation.

Results and discussion

Partridges inoculated with WNV/NY99 and WNV/08 strains showed clinical signs such as weight loss, ru

SUBMITTER: Llorente F 

PROVIDER: S-EPMC10308050 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature