<i>RBL2</i> Regulates Cardiac Sensitivity to Anthracycline Chemotherapy.

ABSTRACT:

Background

Anthracycline chemotherapies cause heart failure in a subset of cancer patients. We previously reported that the anthracycline doxorubicin (DOX) induces cardiotoxicity through the activation of cyclin-dependent kinase 2 (CDK2).

Objectives

The aim of this study was to determine whether retinoblastoma-like 2 (RBL2/p130), an emerging CDK2 inhibitor, regulates anthracycline sensitivity in the heart.

Methods

Rbl2^-/- mice and Rbl2^+/+ littermates received DOX (5 mg/kg/wk for 4 weeks intraperitoneally, 20 mg/kg cumulative). Heart function was monitored with echocardiography. The association of RBL2 genetic variants with anthracycline cardiomyopathy was evaluated in the SJLIFE (St. Jude Lifetime Cohort Study) and CPNDS (Can

SUBMITTER: Xia P 

PROVIDER: S-EPMC10308060 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature