Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice.

ABSTRACT: Physical exercise has been positioned as a promising strategy to prevent and/or alleviate anxiety and depression, but the biological processes associated with its effects on mental health have yet to be entirely determined. Although the prevalence of depression and anxiety in women is about twice that of men, very few studies have examined whether physical exercise could affect mental health differently according to sex. This study examined, in singly-housed mice, the sex-specific effects of voluntary exercise on depressive- and anxiety-like behaviors as well as on different markers along the gut microbiota-immune-brain axis. Male and female C57BL/6N mice had voluntary access to running wheels in their home-cages for 24 days or were left undisturbed in identical home-cages without running

SUBMITTER: Williams ZAP 

PROVIDER: S-EPMC10308214 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature