Characterization of Brain Volume Changes in Aging Individuals With Normal Cognition Using Serial Magnetic Resonance Imaging.

ABSTRACT:

Importance

Characterizing longitudinal patterns of regional brain volume changes in a population with normal cognition at the individual level could improve understanding of the brain aging process and may aid in the prevention of age-related neurodegenerative diseases.

Objective

To investigate age-related trajectories of the volumes and volume change rates of brain structures in participants without dementia.

Design, setting, and participants

This cohort study was conducted from November 1, 2006, to April 30, 2021, at a single academic health-checkup center among 653 individuals who participated in a health screening program with more than 10 years of serial visits.

Exposure

Serial magnetic resonance imaging, Mini-Mental State Examination, health checkup.

M

SUBMITTER: Fujita S 

PROVIDER: S-EPMC10308250 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature