Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with a high mortality rate. On this basis, exploring potential therapeutic targets to meet the unmet needs of IPF patients is important.

Aim

To explore novel hub genes for IPF therapy.

Methods

Here, we used public datasets to identify differentially expressed genes between IPF patients and healthy donors. Potential targets were considered based on multiple bioinformatics analyses, especially the correlation between hub genes and carbon monoxide diffusing capacity of carbon monoxide, forced vital capacity, and patient survival rate. The mRNA levels of the hub genes were determined through quantitative real-time polymerase chain reaction.

Results

We found that TDO2 wa

SUBMITTER: Wang R 

PROVIDER: S-EPMC10308271 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature