OligoR: A Native HDX/MS Data Processing Application Dedicated to Oligonucleotides.

ABSTRACT: Hydrogen-deuterium exchange mass spectrometry (HDX/MS) is increasingly used to study the dynamics of protein conformation. Coupled to native MS, HDX can also characterize the conformations of oligonucleotides and their binding to cations, small molecules, and proteins. Data processing and visualization of native HDX/MS of oligonucleotides requires dedicated software solutions. OligoR is a web-browser-based application that addresses the specific needs of DNA HDX/MS and native MS experiments from raw data in an open format to visualization and export of results. Whole experiments spanning many time points can be processed in minutes for several mass-separated species. To access valuable folding dynamics information, we have developed a simple and robust approach to deconvolute bimodal isoto

SUBMITTER: Largy E 

PROVIDER: S-EPMC10308331 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature