Head-to-head comparison of plasma and PET imaging ATN markers in subjects with cognitive complaints.

ABSTRACT:

Background

Gaining more information about the reciprocal associations between different biomarkers within the ATN (Amyloid/Tau/Neurodegeneration) framework across the Alzheimer's disease (AD) spectrum is clinically relevant. We aimed to conduct a comprehensive head-to-head comparison of plasma and positron emission tomography (PET) ATN biomarkers in subjects with cognitive complaints.

Methods

A hospital-based cohort of subjects with cognitive complaints with a concurrent blood draw and ATN PET imaging (¹⁸F-florbetapir for A, ¹⁸F-Florzolotau for T, and ¹⁸F-fluorodeoxyglucose [¹⁸F-FDG] for N) was enrolled (n = 137). The β-amyloid (Aβ) status (positive versus negative) and the severity of cognitive impairment served as the main outcom

SUBMITTER: Lu J 

PROVIDER: S-EPMC10308642 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature