Nesfatin-3 possesses divalent metal ion binding properties, which remain hidden in the nucleobindin-2 precursor protein.

ABSTRACT:

Background

Nucleobindin-2 (Nucb2) is a multidomain protein that, due to its structure, participates in many physiological processes. It was originally identified in several regions of the hypothalamus. However, more recent studies have redefined and extended the function of Nucb2 far beyond its initially observed role as a negative modulator of food intake.

Results

Previously, we described Nucb2 as structurally divided into two parts: the Zn²⁺-sensitive N-terminal half and the Ca²⁺-sensitive C-terminal half. Here, we investigated the structural and biochemical properties of its C-terminal half, which, after posttranslational processing, yields the formation of a fully uncharacterized peptide product known as nesfatin-3. Nesfatin-3 likely contains all th

SUBMITTER: Skorupska-Stasiak A 

PROVIDER: S-EPMC10308643 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature