A scoping review of statistical methods in studies of biomarker-related treatment heterogeneity for breast cancer.

ABSTRACT:

Background

Many scientific papers are published each year and substantial resources are spent to develop biomarker-based tests for precision oncology. However, only a handful of tests is currently used in daily clinical practice, since development is challenging. In this situation, the application of adequate statistical methods is essential, but little is known about the scope of methods used.

Methods

A PubMed search identified clinical studies among women with breast cancer comparing at least two different treatment groups, one of which chemotherapy or endocrine treatment, by levels of at least one biomarker. Studies presenting original data published in 2019 in one of 15 selected journals were eligible for this review. Clinical and statistical characteristics were extract

SUBMITTER: Sollfrank L 

PROVIDER: S-EPMC10308726 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature