Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis.

ABSTRACT: Accumulating studies have shown the effects of gut microbiota management tools in improving depression. We conducted a meta-analysis to evaluate the effects of prebiotics, probiotics, and synbiotics on patients with depression. We searched six databases up to July 2022. In total, 13 randomized controlled trials (RCTs) with 786 participants were included. The overall results demonstrated that patients who received prebiotics, probiotics or synbiotics had significantly improved symptoms of depression compared with those in the placebo group. However, subgroup analysis only confirmed the significant antidepressant effects of agents that contained probiotics. In addition, patients with mild or moderate depression could both benefit from the treatment. Studies with a lower proportion of females

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10308754 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature