Genetic susceptibility to airway inflammation and exposure to short-term outdoor air pollution.

ABSTRACT:

Background

Air pollution is a large environmental health hazard whose exposure and health effects are unequally distributed among individuals. This is, at least in part, due to gene-environment interactions, but few studies exist. Thus, the current study aimed to explore genetic susceptibility to airway inflammation from short-term air pollution exposure through mechanisms of gene-environment interaction involving the SFTPA, GST and NOS genes.

Methods

Five thousand seven hundred two adults were included. The outcome measure was fraction of exhaled nitric oxide (FeNO), at 50 and 270 ml/s. Exposures were ozone (O₃), particulate matter < 10 µm (PM₁₀), and nitrogen dioxide (NO₂) 3, 24, or 120-h prior to FeNO measurement. In the SFTPA, GST and NOS

SUBMITTER: Bouma F 

PROVIDER: S-EPMC10308777 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature