Effects of stimulus pulse rate on somatosensory adaptation in the human cortex.

ABSTRACT:

Background

Intracortical microstimulation (ICMS) of the somatosensory cortex can restore sensation to people with neurological diseases. However, many aspects of ICMS are poorly understood, including the effect of stimulation on percept intensity over time.

Objective

Here, we evaluate how tactile percepts evoked by ICMS in the somatosensory cortex of a human participant adapt over time.

Methods

We delivered continuous and intermittent ICMS to the somatosensory cortex and assessed the reported intensity of tactile percepts over time in a human participant. Experiments were conducted over approximately one year and linear mixed effects models were used to assess significance.

Results

Continuous stimulation at high frequencies led to rapid decreases in intensity,

SUBMITTER: Hughes CL 

PROVIDER: S-EPMC10308851 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature