Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid.

ABSTRACT: African swine fever virus (ASFV), the cause of a highly contagious hemorrhagic and fatal disease of domestic pigs, has a complex multilayer structure. The inner capsid of ASFV located underneath the inner membrane enwraps the genome-containing nucleoid and is likely the assembly of proteolytic products from the virally encoded polyproteins pp220 and pp62. Here, we report the crystal structure of ASFV p150_△NC, a major middle fragment of the pp220 proteolytic product p150. The structure of ASFV p150_△NC contains mainly helices and has a triangular plate-like shape. The triangular plate is approximately 38 Å in thickness, and the edge of the triangular plate is approximately 90 Å long. The structure of ASFV p150_△NC is not homologous to any of the known viral ca

SUBMITTER: Li H 

PROVIDER: S-EPMC10308890 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature