Metatranscriptomic analysis uncovers prevalent viral ORFs compatible with mitochondrial translation.

ABSTRACT: RNA viruses are ubiquitous components of the global virosphere, yet relatively little is known about their genetic diversity or the cellular mechanisms by which they exploit the biology of their diverse eukaryotic hosts. A hallmark of (+)ssRNA (positive single-stranded RNA) viruses is the ability to remodel host endomembranes for their own replication. However, the subcellular interplay between RNA viruses and host organelles that harbor gene expression systems, such as mitochondria, is complex and poorly understood. Here we report the discovery of 763 new virus sequences belonging to the family Mitoviridae by metatranscriptomic analysis, the identification of previously uncharacterized mitovirus clades, and a putative new viral class. With this expanded understanding of the diversi

SUBMITTER: Begeman A 

PROVIDER: S-EPMC10308907 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature