<b>Dynamic genome-based metabolic modeling of the predominant cellulolytic rumen bacterium <i>Fibrobacter succinogenes</i> S85</b>.

ABSTRACT: Fibrobacter succinogenes is a cellulolytic bacterium that plays an essential role in the degradation of plant fibers in the rumen ecosystem. It converts cellulose polymers into intracellular glycogen and the fermentation metabolites succinate, acetate, and formate. We developed dynamic models of F. succinogenes S85 metabolism on glucose, cellobiose, and cellulose on the basis of a network reconstruction done with the automatic reconstruction of metabolic model workspace. The reconstruction was based on genome annotation, five template-based orthology methods, gap filling, and manual curation. The metabolic network of F. succinogenes S85 comprises 1,565 reactions with 77% linked to 1,317 genes, 1,586 unique metabolites, and 931 pathways. The network was reduced using th

SUBMITTER: Fakih I 

PROVIDER: S-EPMC10308913 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature