Lymph-Node-Based CD3⁺ CD20⁺ Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection.

ABSTRACT: CD4⁺ T follicular helper (T_FH) cells are key targets for human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) replication and contribute to the virus reservoir under antiretroviral therapy (ART). Here, we describe a novel CD3⁺ CD20⁺ double-positive (DP) lymphocyte subset, resident in secondary lymphoid organs of humans and rhesus macaques (RMs), that appear predominantly after membrane exchange between T_FH and B cells. DP lymphocytes are enriched in cells displaying a T_FH phenotype (CD4⁺ PD1^hi CXCR5^hi), function (interleukin 21 positive [IL-21⁺]), and gene expression profile. Importantly, expression of CD40L upon brief in vitro mitogen stimulation identifie

SUBMITTER: Samer S 

PROVIDER: S-EPMC10308947 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature