Vascular and Non-HLA autoantibody profiles in hospitalized patients with COVID-19.

ABSTRACT:

Introduction

Severe COVID-19 illness is characterized by an overwhelming immune hyperactivation. Autoantibodies against vascular, tissue, and cytokine antigens have been detected across the spectrum of COVID-19. How these autoantibodies correlate with COVID-19 severity is not fully defined.

Methods

We performed an exploratory study to investigate the expression of vascular and non-HLA autoantibodies in 110 hospitalized patients with COVID-19 ranging from moderate to critically ill. Relationships between autoantibodies and COVID- 19 severity and clinical risk factors were examined using logistic regression analysis.

Results

There were no absolute differences in levels of expression of autoantibodies against angiotensin II receptor type 1 (AT1R) or endothelial cell prot

SUBMITTER: Lichtenstein B 

PROVIDER: S-EPMC10309004 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature