Hedgehog interacting protein as a circulating biomarker in women with obesity: a cross-sectional study and intervention studies.

ABSTRACT:

Background

Although a study found a significant increase in serum hedgehog interacting protein (HHIP) concentrations in impaired fasting blood glucose, impaired glucose tolerance and newly diagnosed T2DM patients, the variation in circulating HHIP levels in obese individuals remains unknown.

Patients and methods

Gene Set Enrichment Analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were used for differentially expressed genes and signal pathways. The study is comprised of a total of 452 young women, including 248 obese individuals and 204 controls. Circulating HHIP and Adipoq levels were determined with ELISA kits. Euglycemic-hyperinsulinemic clamps (EHC) and oral glucose tolerance test (OGTT) were conducted in every subject. 32 women were given

SUBMITTER: Wang H 

PROVIDER: S-EPMC10309011 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature