Picking winners in cell-cell collisions: Wetting, speed, and contact.

ABSTRACT: Groups of eukaryotic cells can coordinate their crawling motion to follow cues more effectively, stay together, or invade new areas. This collective cell migration depends on cell-cell interactions, which are often studied by colliding pairs of cells together. Can the outcome of these collisions be predicted? Recent experiments on trains of colliding epithelial cells suggest that cells with a smaller contact angle to the surface or larger speeds are more likely to maintain their direction ("win") upon collision. When should we expect shape or speed to correlate with the outcome of a collision? To investigate this question, we build a model for two-cell collisions within the phase field framework, which allows for cell shape changes. We can reproduce the observation that cells with high spe

SUBMITTER: Zadeh P 

PROVIDER: S-EPMC10309154 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature