High Variation in Inner Retinal Reflectivity Predicts Poor Visual Outcome in Patients With Central Retinal Vein Occlusion: SCORE2 Report 21.

ABSTRACT:

Purpose

To assess the association of a novel spectral domain optical coherence tomography biomarker with 6-month visual acuity in in the Study of COmparative Treatments for REtinal Vein Occlusion 2.

Methods

Spectral domain optical coherence tomography volume scans were evaluated for inner retinal hyperreflectivity, quantified by optical intensity ratio (OIR) and OIR variation. Baseline visual acuity letter score (VALS), baseline OCT biomarkers, and month 1 OIR were correlated with VALS at month 6. Regression trees, a machine learning technique yielding readily interpretable models, were used to assess for variable interaction.

Results

Only baseline VALS correlated positively with month 6 VALS in multivariate regression. Regression trees detected a novel functional and

SUBMITTER: Mehta N 

PROVIDER: S-EPMC10309158 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature