Systems Genomics Reveals microRNA Regulation of ICS Response in Childhood Asthma.

ABSTRACT:

Background

Asthmatic patients' responses to inhaled corticosteroids (ICS) are variable and difficult to quantify. We have previously defined a Cross-sectional Asthma STEroid Response (CASTER) measure of ICS response. MicroRNAs (miRNAs) have shown strong effects on asthma and inflammatory processes.

Objective

The purpose of this study was to identify key associations between circulating miRNAs and ICS response in childhood asthma.

Methods

Small RNA sequencing in peripheral blood serum from 580 children with asthma on ICS treatment from The Genetics of Asthma in Costa Rica Study (GACRS) was used to identify miRNAs associated with ICS response using generalized linear models. Replication was conducted in children on ICS from the Childhood Asthma Management Program (CAMP)

SUBMITTER: Sharma R 

PROVIDER: S-EPMC10309175 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature