Increased functional connectivity of amygdala subregions in patients with drug-naive panic disorder and without comorbidities.

ABSTRACT:

Background

Amygdala plays an important role in the neurobiological basis of panic disorder (PD), and the amygdala contains different subregions, which may play different roles in PD. The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the amygdala subregions in PD using resting-state functional magnetic resonance imaging and to explore the relationship between the abnormal spontaneous functional connectivity patterns of the regions of interest (ROIs) and the clinical symptoms of PD patients.

Methods

Fifty-three drug-naïve, non-comorbid PD patients and 70 healthy controls (HCs) were recruited. Seed-based resting-state functional connectivity (rsFC) analyses were conducted using the bilateral amygdalae and its

SUBMITTER: Zhang P 

PROVIDER: S-EPMC10309521 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature