A systematic review of kidney-on-a-chip-based models to study human renal (patho-)physiology.

ABSTRACT: As kidney diseases affect ∼10% of the world population, understanding the underlying mechanisms and developing therapeutic interventions are of high importance. Although animal models have enhanced knowledge of disease mechanisms, human (patho-)physiology may not be adequately represented in animals. Developments in microfluidics and renal cell biology have enabled the development of dynamic models to study renal (patho-)physiology in vitro. Allowing inclusion of human cells and combining different organ models, such as kidney-on-a-chip (KoC) models, enable the refinement and reduction of animal experiments. We systematically reviewed the methodological quality, applicability and effectiveness of kidney-based (multi-)organ-on-a-chip models, and describe the state-of-the-art, strengths and

SUBMITTER: Nguyen VVT 

PROVIDER: S-EPMC10309579 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature