Impact of overweight and obesity on disease activity and remission in systemic lupus erythematosus: A systematic review and meta-analysis protocol.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease that requires treatment with hydroxychloroquine and glucocorticoids. Glucocorticoids are responsible for adverse effects such as increased weight, which can modify the severity and chronicity of autoimmune pathologies.

Aim

To summarize scientific evidence regarding the impact of overweight and obesity on disease activity and remission in SLE.

Methods

The protocol was developed according to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P) and published in the International Prospective Register of Systematic Reviews database (PROSPERO-CRD42021268217). PubMed, Scopus, Embase, and Google Scholar will be searched for observational studies includi

SUBMITTER: Medeiros MCS 

PROVIDER: S-EPMC10309980 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature