Cytomegalovirus in donors for fecal microbiota transplantation, the phantom menace?

ABSTRACT:

Background

Fecal Microbiota Transplantation (FMT) has become the preferred treatment for recurrent Clostridioides difficile Infections (CDI). However, donor screening is a complex process that varies between countries. The primary objective of screening is to prevent the transfer of potential pathogens from the donor to the recipient via feces. Many guidelines recommend Cytomegalovirus (CMV) testing as part of donor screening, but is the risk of CMV transmission well supported by evidence?

Materials/methods

A French prospective cross-sectional multicenter single-arm study estimated the frequency of detection of CMV in the stool of voluntary healthy donors selected for FMT. All preselected donors were tested for CMV antibodies in blood, and if positive, CMV DNA PCR was perfor

SUBMITTER: Galperine T 

PROVIDER: S-EPMC10310004 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature