AIRR community curation and standardised representation for immunoglobulin and T cell receptor germline sets.

ABSTRACT: Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate and relatively complete germline sets, but current sets are known to be incomplete. Established processes for the review and systematic naming of receptor germline genes and alleles require specific evidence and data types, but the discovery landscape is rapidly changing. To exploit the potential of emerging data, and to provide the field with improved state-of-the-art germline sets, an intermediate approach is needed that will allow the rapid publication of consolidated sets derived from these emerging sources. These sets must use a consistent naming scheme and a

SUBMITTER: Lees WD 

PROVIDER: S-EPMC10310305 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature