Association of serum bicarbonate with the development of kidney stones in patients with chronic kidney disease: a retrospective cohort study.

ABSTRACT:

Background

Epidemiological studies demonstrate an association between kidney stones and risk of chronic kidney disease (CKD) and CKD progression. Metabolic acidosis, as a consequence of CKD, results in a reduced urine pH which promotes the formation of some types of kidney stones and inhibits the formation of others. While metabolic acidosis is a risk factor for CKD progression, the association of serum bicarbonate with risk of incident kidney stones is not well understood.

Methods

We used an Integrated Claims-Clinical dataset of US patients to generate a cohort of patients with non-dialysis-dependent CKD with two serum bicarbonate values of 12 to <22 mmol/L (metabolic acidosis) or 22 to <30 mmol/L (normal serum bicarbonate). Primary exposure variables were baseline serum bi

SUBMITTER: Tangri N 

PROVIDER: S-EPMC10310507 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature