The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis.

ABSTRACT: Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause of death in cancer patients. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was isolated from the culture supernatants of not only mitogen-activated peripheral blood mononuclear leukocytes but also malignant glioma cells based on its in vitro chemotactic activity toward human monocytes. MCP-1 was subsequently found to be identical to a previously described tumor cell-derived chemotactic factor thought to be responsible for the accumulation of tumor-associated macrophages (TAMs), and it became a candidate target of clinical intervention; however, the role of TAMs in cancer development was still controversial at the time of the discovery of MCP-1. The in vivo role of MCP-1 in cancer progression w

SUBMITTER: Yoshimura T 

PROVIDER: S-EPMC10310763 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature