Ginsenosides Rg1 regulate lipid metabolism and temperature adaptation in Caenorhabditis elegans.

ABSTRACT:

Background

Obesity is a risk factor for aging and many diseases, and the disorder of lipid metabolism makes it prominent. This study aims to investigate the effect of ginsenoside Rg1 on aging, lipid metabolism and stress resistance.

Methods

Rg1 was administered to Caenorhabditis elegans (C. elegans) cultured in NGM or GNGM. The lifespan, locomotory activity, lipid accumulation, cold and heat stress resistance and related mRNA expression of the worms were examined. Gene knockout mutants were used to clarify the effect on lipid metabolism of Rg1. GFP-binding mutants were used to observe the changes in protein expression.

Results

We reported that Rg1 reduced lipid accumulation and improved stress resistance in C. elegans. Rg1 significantly reduced th

SUBMITTER: Shi H 

PROVIDER: S-EPMC10310868 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature